The Nobel Prize in Chemistry 2022: Click Chemistry

On 5 October 2022, The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2022 to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry”.

 

In Click chemistry, the molecules are connected together with the simple command of "click." Making complicated processes simpler is the focus of the 2022 Nobel Prize in Chemistry. A functional branch of chemistry known as "click chemistry," in which molecular building pieces fit together rapidly and precisely, was established by Barry Sharpless and Morten Meldal. Click chemistry has been expanded by Carolyn Bertozzi, who has begun applying it to living things. For a very long time, chemists have been motivated by the ambition to create ever-more complex compounds. This has frequently involved generating artificial versions of natural compounds with therapeutic qualities in pharmaceutical research. This has produced numerous admirable molecular constructs, but they are typically time- and money-consuming to make.

The theme of this year's Chemistry Prize is working with what is straightforward and uncomplicated rather than overcomplicating things. Even by following a simple path, functional molecules can be created, according to Johan Qvist, Chair of the Nobel Committee for Chemistry. The initiative was established by Barry Sharpless, who is currently receiving his second Nobel Prize in Chemistry. He developed the idea of "click chemistry" around the year 2000, which is a type of straightforward chemistry in which reactions take place rapidly and unintended byproducts are avoided. Shortly after, independently of one another, Morten Meldal and Barry Sharpless presented the azide-alkyne cycloaddition, which is generally regarded as the pinnacle of click chemistry.
Now used frequently, this chemical reaction is both beautiful and effective. It is used, among many other things, to map DNA, produce medications, and make materials that are better suited for their intended application. Carolyn Bertozzi raised the bar for click chemistry. She created click reactions that function inside living beings in order to map crucial but elusive proteins called glycans that are found on the surface of cells. Her bioorthogonal processes happen without interfering with the cell's regular chemistry. Today, people all over the world employ these reactions to investigate cells and monitor biological processes. Researchers have enhanced the targeting of cancer medications using bioorthogonal processes, which are currently being examined in clinical studies.

Chemistry has entered the functionalism age thanks to click chemistry and bioorthogonal reactions. The greatest benefit to humanity is being provided by this. Illustrations Use of the illustrations for non-commercial uses is free. " Johan Jarnestad/The Royal Swedish Academy of Sciences" should be credited.

Illustrations

Illustration: Nobel prize in Chemistry

Illustration: The click reaction that changed chemistry 

Illustration: Bioorthogonal chemistry illuminates the cell

Brief Info about the Winners

Carolyn R. Bertozzi, born 1966 in USA. PhD 1993 from UC Berkeley, CA, USA. Anne T. and Robert M. Bass Professor at Stanford University, CA, USA.

Morten Meldal, born 1954 in Denmark. PhD 1986 from Technical University of Denmark, Lyngby, Denmark. Professor at University of Copenhagen, Denmark.

K. Barry Sharpless, born 1941 in Philadelphia, PA, USA. PhD 1968 from Stanford University, CA, USA. W. M. Keck Professor at Scripps Research, La Jolla, CA, USA.

 

Prize amount: 10 million Swedish kronor, to be shared equally between the Laureates.